In separate studies both published today, researchers at Washington University mapped the genomes of two types of cancer: endometrial cancer, and acute myeloid leukemia.
Both studies are part of project, an effort funded by the National Institutes of Health to study the genetic basis of 20 major human cancers.
Washington University genomicist helped lead the study on , which affects the lining of the uterus.
Mardis, who co-directs The Genome Institute at Washington University, says she and her colleagues identified several new subtypes of the disease that will probably require different types of treatment.
They also found that the most deadly form of endometrial cancer, known as serous, is genetically similar to severe types of and .
鈥淎nd what we propose in the paper is that moving forward, these three tumor types might be studied together in clinical trials, to effect a better cure rate for women with one of the three types of cancer,鈥� Mardis said.
Mardis' study on endometrial cancer is published in the journal .
A second study, on (AML), a cancer of the blood and bone marrow, was co-led by Washington University physician scientist and , who directs The Genome Institute with Elaine Mardis.
Ley says he and his colleagues sequenced the DNA and associated genetic products of AML tumor cells and compared them to those of healthy tissue. They identified mutations and also looked at gene expression 鈥� whether or not the genes were producing proteins.
鈥淚t鈥檚 created a treasure-trove of new information about the disease, about the mutations that cause it, about how they interact, and what their consequences are for patients,鈥� Ley said.
He says it could take more than a decade to analyze all the data, but that eventually the information from this study could be used to guide treatment decisions, like whether or not patients need risky and expensive stem cell transplants.
Ley's study on acute myeloid leukemia is published in the .
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