Many people who get sick with COVID-19 continue to have wide-ranging health problems months after they recover from their initial infection, researchers at the Veterans Affairs St. Louis Health Care System have found.
In a in the journal Nature, the researchers wrote that even after COVID-19 patients no longer tested positive for the coronavirus, they continued to have serious or chronic health issues. The study of more than 73,000 COVID-19 patients found that they sought care and medications more frequently than people who did not get sick.
鈥淲hat we鈥檙e seeing in acute COVID, we鈥檙e seeing literally the tip of the iceberg,鈥� said Dr. Ziyad Al-Aly, a doctor at the St. Louis VA hospital and one of the study鈥檚 authors. 鈥淚f you start looking at long COVID, that鈥檚 what鈥檚 beneath that tip. 鈥� Some people call this our next big health crisis. I don鈥檛 think that that is an exaggeration.鈥�
The patients saw higher incidences of issues 鈥� such as heart and kidney problems and mental health disorders. The most prevalent were respiratory symptoms. The group of so-called COVID-19 long-haulers developed problems in practically every organ, Al-Aly said.
鈥淥ur approach was designed to leave literally no stone unturned,鈥� Al-Aly said. 鈥淲e looked at every single disease we know exists. Our report shows the burden of COVID is substantial, it鈥檚 not really small, and it can take different shapes and different forms in different people.鈥�
Patients who recovered from COVID-19 also had higher incidences of depression, diabetes and other chronic diseases.
The study鈥檚 findings confirm what Dr. Maureen Lyons, director of Washington University鈥檚 new Care and Recovery After COVID clinic, is
鈥淐ommon symptoms include profound fatigue, inability to concentrate, inability to focus, headache, chest pain, chest pressure, high heart rates, and really symptoms that span every organ system,鈥� she said. 鈥淭he impact of COVID, even potentially what seems like a mild case initially, can be quite impactful and can last a long period of time and truthfully an unknown period of time.鈥�
Most of the patients with long COVID who come to the clinic did not go to the hospital when they first got sick, and many are younger, healthy people, she said. The average clinic patient is in their mid-40s.
The VA study found that while people with more severe cases of COVID-19 who required hospitalization were more likely to have continuing health problems, even those who had relatively mild cases of the disease developed long-term health problems.
The study's authors say it is not clear if or how the coronavirus is related to such long-term health issues. The ongoing health disorders could be caused by the virus continuing to live inside patients鈥� bodies, they wrote.
They also say it鈥檚 possible that the virus could cause a patient鈥檚 immune system to go into overdrive and make them sick.
Most of the VA patients in the study are men, which reflects the organization鈥檚 overall patient mix. It鈥檚 possible long COVID could be more widespread in women, the study鈥檚 authors said.
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